EXPRESSION OF ANGIOPOIETIN-2 AND VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-3 CORRELATES WITH LYMPHANGIOGENESIS AND ANGIOGENESIS AND AFFECTS SURVIVAL OF ORAL SQUAMOUS CELL CARCINOMA.

Expression of angiopoietin-2 and vascular endothelial growth factor receptor-3 correlates with lymphangiogenesis and angiogenesis and affects survival of oral squamous cell carcinoma.

BACKGROUND: Both Ang-2 and VEGFR-3 are major regulators of angiogenesis and lymphangiogenesis, respectively, and thus may affect prognosis of OSCC.We sought to determine the associations between Ang-2 and VEGFR-3 expression and survival of OSCC.METHODS: Ang-2 and VEGFR-3 expression was determined immunohistochemically in tumor tissues from 112 pati

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Small-Molecule PROTACs for Cancer Immunotherapy

Unsatisfactory physicochemical properties of macromolecular drugs seriously hinder their application in tumor immunotherapy.However, these problems can be effectively solved by small-molecule compounds.In the promising field of small-molecule drug development, proteolysis targeting chimera (PROTAC) offers a novel mode of action in the interactions

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Entre mythe et histoire : Le roman de Brutus et Dorothée dans le Victorial de Gutierre Díaz de Games (1436)

Cet article a pour but d’étudier à partir Horn Bags d’une double perspective « Le roman de Brutus et Dorothée » inséré dans le Victorial de Gutierre Díaz de Games.Il s’agit, dans un premier temps, de retracer la circulation et la réception du mythe troyen dans la péninsule Ibérique, ceci afin de déterminer la part de création e

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