Expression of angiopoietin-2 and vascular endothelial growth factor receptor-3 correlates with lymphangiogenesis and angiogenesis and affects survival of oral squamous cell carcinoma.
BACKGROUND: Both Ang-2 and VEGFR-3 are major regulators of angiogenesis and lymphangiogenesis, respectively, and thus may affect prognosis of OSCC.We sought to determine the associations between Ang-2 and VEGFR-3 expression and survival of OSCC.METHODS: Ang-2 and VEGFR-3 expression was determined immunohistochemically in tumor tissues from 112 pati